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For example, if you’re overusing opioids or barbiturates, your doctor may prescribe triptans or nonsteroidal anti-inflammatory drugs (NSAIDs). Patients must gradually taper off caffeine, barbiturates, and opioids to avoid abstinence syndrome: In addition to severe pain, abrupt withdrawal of opioids or barbiturates can cause irritability, sleeplessness, and sometimes seizures, says Dr. Lipton, adding that patients overusing barbiturate or opioid analgesics may require medically supervised withdrawal and pain management with intravenous drugs in a hospital, . Yes, but patients remain at risk for relapse if they start taking too much medication again, says Dr.
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